Bottom-Drive RMG — GMP Hygienic / HPAPI Configuration

A bottom-drive RMG mounts the main impeller motor beneath the bowl — driving the impeller upward from below through a sealed bearing assembly — creating an unobstructed top opening for spray systems, sampling, and contained charging. Processing 10–2,000 L, it provides superior GMP top-access, easier cleaning validation, and reduced cross-contamination risk — the preferred configuration for high-containment HPAPI and sterile granulation suites requiring OEB 4–5 classification.

What It Is

How It Works

What It Is

How It Works

Challenges

Solutions

Double Mechanical Seal with Pressurised Barrier Fluid (API-682): Barrier fluid above process pressure — zero wet mass ingress at any operating condition.
Swept-Base Impeller Blade (3 mm Root Clearance): Blade root profiled to within 3 mm of bowl base — dead zone <0.01% of bowl capacity.
Anti-Vibration Motor Mount (Elastomeric Isolators): Natural frequency above 2× maximum impeller speed — vibration not transmitted.
Dedicated CIP Spray Ring at Seal Zone (360°): 360° ring nozzle delivers 3 m/s CIP velocity at all seal surfaces — validated by TOC.
ROI Justification for HPAPI Containment: Containment cost avoidance for OEB 4–5 products justifies the bottom-drive capital premium.

Applications

Pharmaceutical (HPAPI): OEB 4–5 high-potency API wet granulation — contained charging, spray, and discharge.
Sterile Manufacturing: Aseptic wet granulation for sterile solid dosage — validated closed system.
Nutraceuticals: High-value probiotic and enzyme supplement granulation with closed processing.
Biotechnology: Enzyme-coated granule and biologically active granule wet agglomeration.
Chemical: Sensitiser compound granulation requiring HPAPI-equivalent containment.

Models & Capacities

1B. Bottom-Drive RMG — Models & Capacities
Model	Net Vol. [L]	Batch Size [kg]	Impeller Speed [RPM]	Chopper Speed [RPM]	Impeller Motor [kW]	Chopper Motor [kW]	Containment OEB Level	Bowl Ø [mm]	Bowl H [mm]	Overall H [mm]
RMG-BD-010	10	3–6	100–500	1,000–3,000	2.2	0.55	OEB 1–4	400	320	1,800
RMG-BD-025	25	8–15	100–400	1,000–3,000	5.5	0.75	OEB 1–4	550	430	2,100
RMG-BD-060	60	18–36	100–350	1,000–3,000	11	1.5	OEB 1–5	750	580	2,500
RMG-BD-150	150	45–90	100–300	1,000–3,000	18.5	2.2	OEB 1–5	1,000	780	3,000
RMG-BD-300	300	90–180	80–250	1,000–2,500	30	3.0	OEB 1–5	1,300	980	3,600
RMG-BD-600	600	180–360	80–200	1,000–2,500	45	5.5	OEB 1–5	1,600	1,200	4,200
RMG-BD-1200	1,200	360–720	60–180	1,000–2,000	90	7.5	OEB 1–5	2,000	1,500	5,200
RMG-BD-2000	2,000	600–1,200	50–150	500–1,500	132	11	OEB 1–5	2,400	1,800	6,200